Concentration of Receptors With Affinity for Cannabidiol and Cannabinol and the Effect on Chronic Orofacial Pain of Muscle Origin

Enrolling by invitation

Conditions studied: Myalgia, Muscle Pain, Orofacial Pain, Headache, Tension, Headaches Muscular

In brief

The main aim of the presented project will be to examine the concentration of selected receptors (CB1, CB2, TRPV-1) showing affinity for binding to cannabidol (CBD) and cannabinol (CBN) in blood samples collected from people with chronic pain in the masticatory muscles and from people without this pain. Moreover, study participants will be examined by a qualified doctor, according to the validated and standardized international DC/TMD protocol (Diagnostic Criteria for Temporomandibular Disorders) and the criteria included in ICOP-1 (International Classification of Orofacial Pain, 1st edition). The nature and duration of pain, psychoemotional state and central sensitization (the phenomenon of increased reactivity of the nervous system to stimuli) will be determined using validated questionnaires. The obtained results will be subjected to statistical analysis in order to check the relationships between the examined parameters.

Key facts

Study ID

NCT06405646

Run by

Wroclaw Medical University

People needed

102

Starts

2025-04-01

Expected to finish

2026-12-01

Last updated by the study team

2026-03-06

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• age over 18, under 80
• the presence of chronic pain in the muscles of the masticatory system, which lasts for more than 3 months in accordance with the international criteria included in ICOP-1.

You may not qualify if…

• people under 18 years of age
• pregnant or breastfeeding women,
• obese people,
• people with active cancer,
• people with severe systemic diseases, including genetic and neurological diseases,
• people with severe mental illnesses and taking psychoactive substances, people who are taking or have taken antidepressants and/or myorelaxants and/or other drugs that affect neuromuscular activity in the last 12 months
• people addicted to alcohol, drugs and other psychoactive substances
• condition after craniofacial injuries

Where it is running

• Wroclaw Medical University — Wroclaw, Poland

Full record on ClinicalTrials.gov

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