Facilitating Neuroplastic Changes of Acute Stroke Survivors
Recruiting now · Phase 1/Phase 2
Conditions studied: Stroke
In brief
This project will develop a wearable rehabilitation robot suitable for in-bed acute stage rehabilitation. It involves robot-guided motor relearning, passive and active motor-sensory rehabilitation early in the acute stage post-stroke including patients who are paralyzed with no motor output. The early acute stroke rehabilitation device will be evaluated in this clinical trial.
Key facts
- Study ID
- NCT06404268
- Run by
- University of Maryland, Baltimore
- People needed
- 68
- Starts
- 2025-06-01
- Expected to finish
- 2028-08-31
- Last updated by the study team
- 2026-07-23
Who can join
Age: 30 and older, up to 85. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Acute first time unilateral hemispheric stroke (hemorrhagic or ischemic stroke, 24 hours after admission to 1 month post-stroke at the start of the proposed treatment)
- Hemiplegia or hemiparesis
- 0≤Manual Muscle Testing (MMT)<=2
- Age 30-85
- Ankle impairments including stiff calf muscles and/or inadequate dorsiflexion
You may not qualify if…
- Medically not stable
- Associated acute medical illness that interferes with ability to training and exercise
- No impairment or very mild ankle impairment of ankle
- Severe cardiovascular problems that interfere with ability to perform moderate movement exercises
- Cognitive impairment or aphasia with inability to follow instructions
- Severe pain in legs
- Severe ankle contracture greater than 15° plantar flexion (when pushing ankle to dorsiflexion)
- Pressure ulcer, recent surgical incision or active skin disease with open wounds present below knee
Where it is running
- University of Maryland Baltimore — Baltimore, Maryland, United States (enrolling)
- UMROI — Baltimore, Maryland, United States (enrolling)
- TIRR Memorial Hermann — Houston, Texas, United States (enrolling)
Full record on ClinicalTrials.gov
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