A Study of AMG 732 in Healthy Participants and Participants With Thyroid Eye Disease
Recruiting now · Phase 1/Phase 2 · Has a placebo group
Conditions studied: Thyroid Eye Disease
In brief
The primary objective of Part A of this study is to investigate the safety and tolerability of AMG 732 after single subcutaneous (SC) doses. The primary objective of Part B of this study is to investigate the efficacy of AMG 732 in participants with Thyroid Eye Disease (TED) after multiple SC doses.
Key facts
- Study ID
- NCT06401044
- Run by
- Amgen
- People needed
- 88
- Starts
- 2024-05-30
- Expected to finish
- 2027-08-13
- Last updated by the study team
- 2026-07-10
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
Where it is running
- Applied Research Center of Arkansas — Little Rock, Arkansas, United States (enrolling)
- Amy Patel Jain MD — Newport Beach, California, United States (enrolling)
- Levenson Eye Associates — Jacksonville, Florida, United States (enrolling)
- Ilumina Medical Research — Kissimmee, Florida, United States (enrolling)
- Sarasota Retina Institute — Sarasota, Florida, United States (enrolling)
- Vision Medical Research, Inc. — Orland Park, Illinois, United States (enrolling)
- Massachusetts Eye and Ear Infirmary — Boston, Massachusetts, United States (enrolling)
- Ppd Las Vegas Research Unit — Las Vegas, Nevada, United States (enrolling)
- Erie Retina Research — Erie, Pennsylvania, United States (enrolling)
- Baylor College of Medicine Medical Center — Houston, Texas, United States (enrolling)
- Consano Clinical Research, LLC — Shavano Park, Texas, United States (enrolling)
- West Virginia University — Morgantown, West Virginia, United States (enrolling)
- Macquarie University — North Ryde, New South Wales, Australia (enrolling)
- North Shore Private Hospital — St Leonards, New South Wales, Australia (enrolling)
- Vancouver General Hospital — Vancouver, British Columbia, Canada (enrolling)
- Santé Québec Est-de-l'Île-de-Montréal - Universitaire — Montreal, Quebec, Canada (enrolling)
- CHU de Québec-Université Laval - CUO-Recherche Clinique, Hopital du Saint-Sacrement — Québec, Quebec, Canada (enrolling)
- Centre Hospitalier Universitaire de Nantes - Hopital Nord Laennec — Nantes, France (enrolling)
- Hopital Pitie-Salpetriere — Paris, France (enrolling)
- Universitaetsklinikum Essen — Essen, Germany (enrolling)
- Buergerhospital und Clementine Kinderhospital gGmbH — Frankfurt am Main, Germany (enrolling)
- Universitaetsklinikum Freiburg — Freiburg im Breisgau, Germany (enrolling)
- Universitaetsklinikum Leipzig AoeR — Leipzig, Germany (enrolling)
- General Hospital of Athens Laiko — Athens, Greece (enrolling)
- Ippokratio General Hospital of Thessaloniki — Thessaloniki, Greece (enrolling)
Full record on ClinicalTrials.gov
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