Multivessel Balloon Occlusion to Investigate Obstructive Coronary Artery Disease and aNgina
Recruiting now · Not applicable · Has a placebo group
Conditions studied: Stable Angina, Multivessel Coronary Artery Disease
In brief
ORBITA-MOON is a double-blinded, placebo-controlled experimental study that aims to understand how the different coronary artery stenoses contribute to overall clinical angina in patients with multi-vessel coronary artery disease. This study will investigate the symptoms conferred by each stenosis, induced by experimental ischaemia, for 60 patients with multi-vessel coronary artery disease.
Key facts
- Study ID
- NCT06400290
- Run by
- Imperial College London
- People needed
- 60
- Starts
- 2024-06-13
- Expected to finish
- 2027-04-01
- Last updated by the study team
- 2025-06-06
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Eligibility for PCI due to angina
- Anatomical evidence of significant multi-vessel coronary stenosis defined by either:
- ≥70% stenosis in two or more coronary arteries of ≥2.5mm visual diameter stenosis, on invasive coronary angiography (ICA)
- Severe stenosis in ≥2 coronary arteries of ≥ 2.5mm visual diameter stenosis, on CTCA
- Physiological evidence of ischaemia with a positive test corresponding to the coronary arteries to be stented, on at least one of the following:
- dobutamine stress echocardiogram
- cardiac MRI
- myocardial perfusion study
- invasive metrics of coronary physiology
You may not qualify if…
- Recent acute coronary syndrome
- Previous coronary artery by-pass graft surgery (CABG)
- Significant left main stem disease
- Chronic total occlusion in the target artery(s)
- Moderate to severe valvular disease
- Moderate to severe left ventricular impairment
- Contraindication to PCI or a drug-eluting stents
- Contraindication to antiplatelet therapy
- Contraindication to adenosine
- Pregnant
- Inability to consent
Where it is running
- University Hospital Southampton — Southampton, United Kingdom (enrolling)
- Royal Bournemouth Hospital — Bournemouth, United Kingdom (enrolling)
- Royal Sussex County Hospital — Brighton, United Kingdom (enrolling)
- Imperial College NHS Trust — London, United Kingdom (enrolling)
- Royal Free London NHS Foundation Trust — London, United Kingdom (enrolling)
- St Georges University Hospital — London, United Kingdom (enrolling)
- Nottingham City Hospital — Nottingham, United Kingdom (enrolling)
- Essex Cardiothoracic Centre — Basildon, United Kingdom (enrolling)
- Portsmouth Hospitals University NHS Trust — Portsmouth, United Kingdom
Full record on ClinicalTrials.gov
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