Ventilatory Parameters in Predicting Outcomes in ARDS Patients

Recruiting now

Conditions studied: ARDS, Mechanical Power

In brief

This is a single-centre prospective observational study aimed to determine if Pocc (occlusion pressure at 100 msec), TCe ( Expiratory time constant ), Mechanical Stress power, Ventilatory ratio and C20/Cdyn would predict outcomes in patients with moderately severe ARDS (Acute respiratory distress syndrome), who are on mechanical ventilation

Key facts

Study ID

NCT06400095

Run by

CentraCare

People needed

50

Starts

2023-06-01

Expected to finish

2025-07-01

Last updated by the study team

2024-08-22

Who can join

Age: 19 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with Acute respiratory failure needing mechanical ventilation
• Diagnosis of Severe ARDS with severity: PF ratio < 150, with PEEP/CPAP > 5

You may not qualify if…

• r2 < 0.95, monitored on the ventilator
• Expiratory flow that is not first-order or non-exponential decay
• Patients with Nor-epinephrine requirements > 0.1 mcg/kg/min within 2 hours of intubation
• Patients requiring ECMO ( Extracorporeal membrane oxygenation)
• Patients with COPD or pulmonary fibrosis with a premorbid FEV1 < 1.5 L
• Severe atherosclerotic vascular disease
• Patients with a chest tube, intra-abdominal hypertension or with its risk factors
• Patients with structural heart disease including pulmonary hypertension (RVSP > 45) and heart failure
• All comfort care orders in the ICU
• Patients who underwent tracheostomy

Where it is running

• St Cloud Hospital — Saint Cloud, Minnesota, United States (enrolling)

Full record on ClinicalTrials.gov

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