Prospective Multicenter Research on Donor and Recipient Management Strategies to Improve Lung Transplant Outcomes

Recruiting now

Conditions studied: Lung Transplant; Complications, Lung Transplant; Infection or Inflammation, Lung Transplant Rejection, Lung Transplant Failure

In brief

This project aims to collect detailed clinical data, blood samples, and patient-reported outcomes from 2,600 lung transplant candidates, donors, and recipients at Lung Transplant Centers. The goal is to create a robust resource for various research objectives, including studying the impact of variations in donor and medical practices on clinical outcomes. The project also seeks to identify serum biomarkers associated with or predictive of specific post-transplant complications and conditions.

Key facts

Study ID

NCT06399302

Run by

Duke University

People needed

2600

Starts

2024-09-03

Expected to finish

2027-06-30

Last updated by the study team

2026-08-07

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Able to understand and provide informed consent
• ≥ 18 years of age at the time of written informed consent
• Anticipated listing or listed for a single or bilateral cadaveric donor lung transplant or having received a lung transplant within 30 days
• Participants undergoing repeat lung transplantation or multi-organ transplantation are eligible if they meet the inclusion/exclusion criteria.

You may not qualify if…

• Unwillingness of a participant or legally authorized representative (LAR) to give written informed consent or comply with study protocol
• Pregnancy or plans to become pregnant
• Past or current medical problems or findings from physical examination or laboratory testing, which, in the opinion of the investigator, may pose additional risks from participation in the study, may interfere with the participant's ability to comply with study requirements or that may impact the quality or interpretation of the data obtained from the study.

Where it is running

• University of California Los Angeles — Los Angeles, California, United States (enrolling)
• University of California at San Francisco — San Francisco, California, United States (enrolling)
• Stanford University Medical Center — Stanford, California, United States (enrolling)
• University of Miami — Miami, Florida, United States (enrolling)
• Johns Hopkins University — Baltimore, Maryland, United States (enrolling)
• Brigham and Womens Hospital — Boston, Massachusetts, United States (enrolling)
• University of Michigan — Ann Arbor, Michigan, United States (enrolling)
• University of Minnesota — Minneapolis, Minnesota, United States (enrolling)
• New York University — New York, New York, United States (enrolling)
• Columbia University — New York, New York, United States (enrolling)
• Duke University Medical Center — Durham, North Carolina, United States (enrolling)
• University of Pennsylvania — Philadelphia, Pennsylvania, United States (enrolling)
• University of Pittsburgh Medical Center — Pittsburgh, Pennsylvania, United States (enrolling)
• Vanderbilt University Medical Center — Nashville, Tennessee, United States (enrolling)
• Houston Methodist Hospital, Texas Medical Center — Houston, Texas, United States (enrolling)
• Inova Fairfax Hospital — Falls Church, Virginia, United States (enrolling)
• University of Washington — Seattle, Washington, United States (enrolling)
• University of Wisconsin Hospital and Clinics — Madison, Wisconsin, United States (enrolling)
• University Health Network — Toronto, Canada, Canada (enrolling)

Full record on ClinicalTrials.gov

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