Effect of Dexmedetomidine and Esketamine on Catheter-related Bladder Discomfort
Recruiting now · Phase 4 · Has a placebo group
Conditions studied: Urinary Catheter, Catheter-related Bladder Discomfort, Dexmedetomidine, Esketamine
In brief
Catheter-related bladder discomfort (CRBD) is common in patients awaking from general anesthesia with an urinary catheter. We suppose that that use of dexmedetomidine and/or esketamine during anesthesia may reduce the occurrence of CRBD. This 2x2 factorial randomized trial is designed to explore the effects of esketamine, dexmedetomidine, and their combination on the occurrence CRBD in patients undergoing transurethral urological surgery.
Key facts
- Study ID
- NCT06399185
- Run by
- Peking University First Hospital
- People needed
- 1740
- Starts
- 2024-06-06
- Expected to finish
- 2027-05-01
- Last updated by the study team
- 2025-07-31
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Aged 18 years or above;
- Scheduled to undergo transurethral bladder or prostate surgery (including transurethral resection of bladder tumor, transurethral resection of prostate, and transurethral thulium laser prostatectomy) under general anesthesia;
- Required postoperative retention of a three-chamber urinary catheter.
You may not qualify if…
- Indwelling urinary catheters or chronic analgesic therapy for ≥1 month before surgery;
- Uncontrolled hypertension before surgery (resting ward systolic pressure >180 mmHg or diastolic pressure >110 mmHg);
- Severe bradycardia (heart rate ≤50 beats per minute), sick sinus syndrome, or atrioventricular block of degree II or above without pacemaker, or having myocardial infarction, severe heart insufficiency (New York Heart Association class ≥3), or tachyarrhythmia within a year;
- Preoperative history of schizophrenia, epilepsy, Parkinson's disease, myasthenia gravis, or intracranial hypertension;
- Preoperative history of hyperthyroidism and pheochromocytoma;
- Inability to communicate due to coma, severe dementia, or language barrier before surgery;
- Severe liver dysfunction (Child-Pugh grade C), severe renal dysfunction (receiving dialysis before surgery), or Amercian Society of Anesthesiologists classification ≥IV;
- Scheduled admission to the intensive care unit with endotracheal intubation after surgery;
- Other conditions that are considered unsuitable for study participation.
Where it is running
- Peking University First Hospital — Beijing, Beijing Municipality, China (enrolling)
- Peking University Shenzhen Hospital — Shenzhen, Guangdong, China (enrolling)
Full record on ClinicalTrials.gov
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