Obesity Management for Kidney TRANSPLANTation: OK-TRANSPLANT 2

Recruiting now · Phase 4

Conditions studied: Obesity, Chronic Kidney Disease

In brief

OK-TRANSPLANT 2 is a vanguard study for a large randomized, pragmatic, open-label trial. We will randomize participants with obesity, high-risk CKD/dialysis who are hoping for lose weight for the purpose of kidney transplant. Subjects will either be enrolled on a virtual weight management program or continue their usual care.

Key facts

Study ID

NCT06396416

Run by

Western University, Canada

People needed

60

Starts

2024-09-26

Expected to finish

2026-12-01

Last updated by the study team

2026-06-29

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults aged 18 years or older
• BMI; 35 kg/m\^2
• 10% risk of ESKD requiring renal replacement therapy over 2 years or receiving dialysis

You may not qualify if…

• Known contraindication to a GLP-1RA (pancreatitis, personal or family history of medullary thyroid cancer, hypersensitivity)
• Type 1 diabetes
• No access to semaglutide via drug coverage
• Pregnant, breastfeeding or planning to become pregnant
• Currently in a GLP-1RA or GLP-1RA/GIP study or planning to be in one

Where it is running

• London Health Sciences Centre — London, Ontario, Canada (enrolling)

Full record on ClinicalTrials.gov

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