Structural and Functional Networks in ALS: An Insight Into Pseudobulbar Affect

Recruiting now · Not applicable

Conditions studied: Amyotrophic Lateral Sclerosis, Pseudobulbar Affect

In brief

The investigators aim to elucidate characteristics of structural and functional brain connectivity in patients with amyotrophic lateral sclerosis (ALS) and pseudobulbar affect (PBA) using diffusion kurtosis imaging (DKI) and magnetoencephalography (MEG).

Key facts

Study ID

NCT06396260

Run by

Aalborg University Hospital

People needed

50

Starts

2024-05-26

Expected to finish

2026-12-31

Last updated by the study team

2025-01-29

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Diagnosed with ALS in the last 6 months according to Gold Coast Criteria

You may not qualify if…

• - Lack of ability to answer survey through own ability or through a surrogate, for example by hand controlled, eye-controlled computer and/or tablet, or through telephone interview.
• Lack of ability to cooperate.
• Pregnancy
• Drug addiction defined as the non-prescribed use of cannabis, opioids, or other narcotics.
• Alcohol addiction defined as over 21 units weekly.
• Lesional neurological diseases, such as stroke, tumor or multiple sclerosis
• Epilepsy
• Neurodegenerative diseases other than ALS
• Severe psychiatric disease such as major depression disorder, bipolar disease or schizophrenia
• Contraindication for MRI and MEG scan according to hospital guidelines
• Severe liver or kidney disease
• Dysregulated heart disease
• Ongoing treatment with any antidepressants or any antipsychotics at recruitment.
• Diagnosed with frontotemporal dementia.

Where it is running

• Aalborg University hospital — Aalborg, Northern Jutland, Denmark (enrolling)

Full record on ClinicalTrials.gov

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