Epidemiology and Treatment Strategy of Open Respiratory Phenotype in Critically Ill Patients
Recruiting now · Not applicable
Conditions studied: Mechanical Ventilation Pressure High, Critical Illness
In brief
Monitoring airway pressure is essential for patients with mechanical ventilation. However, static airway pressure does not reflect alveolar pressure at all. Airway pressure is supposed to completely interrupt the communication between proximal airway opening and the distal alveolar and/or small airway structures. In this condition, some alveoli may still be inflated but do not communicate with proximal airways and auto-PEEP will give a biased estimated of mean alveolar pressure. To be note, distinguishing the airway closure and alveolar collapse can be challenging at times. The quasi-static PV curve is a useful bedside tool to set mechanical ventilation, which may help us to identify the airway closure and alveolar collapse. Meanwhile, the quasi-static PV curve can only reflects a global behaviour of the lung, while EIT may be a useful tool to assess the regional information on airway closure and alveolar collapse.
Key facts
- Study ID
- NCT06393179
- Run by
- Southeast University, China
- People needed
- 60
- Starts
- 2024-05-30
- Expected to finish
- 2024-08-30
- Last updated by the study team
- 2024-08-16
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adult patients undergoing controlled mechanical ventilation
- The duration of endotracheal intubation < 48 hrs
You may not qualify if…
- Severe hemodynamic instability
- Severe chronic lung disease requiring long-term home oxygen therapy
- Patients without analgesic sedation
- Decline to participate in the study
- Refusal to sign informed consent
Where it is running
- Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University — Nanjing, Jiangsu, China (enrolling)
Full record on ClinicalTrials.gov
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