The Stress-obesity Axis: a Metabolomics Approach Towards Personalized Nutrition in Adolescents
Recruiting now
Conditions studied: Pediatric Obesity
In brief
The ultimate aim of this project is to establish a validated strategy that allows for personalized intervention in adolescents (11 to 17 years) whom are assigned a state of overweight or obesity. The investigators will assess the following hypotheses: * Weight condition is reflected by the fecal metabolome (WP1) * Emotional stress is implicated in weight condition (WP1) * Functionality of the gut microbiome is related to the diet-stress-obesity axis (WP2) * Dietary pattern impacts the fecal metabolome and gut microbiome (WP2) * Personalized dietary intervention outperforms generalized dietary approaches (WP3) Participants will: * Produce a saliva, stool and hair sample * Fill in questionnaires regarding mental health, medical health and demographic information * Fill in a food frequency questionnaire and a 24-hrecalls * Be measured (height, weight, fat% and waist circumference) The samples will be analyzed using a technique called metabolomics to identify biomarker candidates with diagnostic and/or prognostic potential. Additionally, microbiome analysis will be performed to map the microbiome of all groups.
Key facts
- Study ID
- NCT06391671
- Run by
- University Ghent
- People needed
- 750
- Starts
- 2022-01-11
- Expected to finish
- 2027-07-01
- Last updated by the study team
- 2024-04-30
Who can join
Age: 11 and older, up to 17. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Age 11-17 years
You may not qualify if…
- Obesity/overweight
- Type 1 diabetes
- Medical conditions including pancreatic failure
- Developmental and hormonal disorders. E.g. thyroid problems, adrenal problems, Kallmann's syndrome, Klinefelter's syndrome, Prader-Willi syndrome (PWS), Congenital hypogonadotropic hypogonadism (CHH), ...
- Pregnancy
- In treatment with systemic concentrations of corticosteroids (cortisone). Eg cortisone/betamethasone/Dexamethasone/Fludrocortisone/Hydrocortisone in pill form or administration by injections.
Where it is running
- AZ Jan Palfijn Gent, Oost-Vlaanderen, Belgium, 9000 — Ghent, Oost-Vlaanderen, Belgium (enrolling)
- Ghent University Hospital — Ghent, Oost-Vlaanderen, Belgium (enrolling)
- Clairs Vallons — Ottignies-Louvain-la-Neuve, Waals Brabant, Belgium (enrolling)
- Zeepreventorium — De Haan, West-Vlaanderen, Belgium (enrolling)
- AZ Delta — Roeselare, West-Vlaanderen, Belgium (enrolling)
- UZ Antwerpen — Antwerp, Belgium (enrolling)
- ZNA Middelheim — Antwerp, Belgium (enrolling)
Full record on ClinicalTrials.gov
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