Passive Leg Raise and Mini-fluid Challenge Effect on Various Cardiac Output Surrogates for Fluid Responsiveness

Recruiting now

Conditions studied: Fluid Responsiveness

In brief

In the critically ill population, fluid administration in an unstable patient is perhaps the most common intervention that is performed. Uncorrected hypovolemia with inappropriate vasopressors lead to organ hypoperfusion where as overzealous fluid administration especially in ARDS (Adult respiratory distress syndrome) can increase mortality. It has been estimated that only 50% of hemodynamically unstable critically ill patients are volume responsive, hence dynamic assessment of preload responsiveness has been proposed to better identify those individuals who would benefit from fluid bolus.

Key facts

Study ID

NCT06390423

Run by

CentraCare

People needed

64

Starts

2023-07-01

Expected to finish

2025-06-01

Last updated by the study team

2024-08-22

Who can join

Age: 30 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age between 30 - 90 years
• Diagnosis of Vasodilatory Shock with no other obvious cause of hypotension
• Diagnosis of ARDS with PF ratio < 150 , PEEP > 8
• Patients who are under paralysis or deeply sedated, on a mechanical ventilator

You may not qualify if…

• Patients with arrhythmias including atrial fibrillation
• Patients with chest tube, intra-abdominal hypertension or with its risk factors
• Patients with structural heart disease including pulmonary hypertension (RVSP > 45) and heart failure
• Patients on extracorporeal support such as ECMO, CRRT or MCS.
• Patients with COPD with a premorbid FEV1 < 1.5 L
• Severe atherosclerotic vascular disease

Where it is running

• St Cloud Hospital — Saint Cloud, Minnesota, United States (enrolling)

Full record on ClinicalTrials.gov

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