Effect of Transcutaneous Auricular Neurostimulation on Cognitive Performance in a Laboratory Model of Acute Stress Reaction

Completed · Not applicable · Has a placebo group

Conditions studied: Acute Stress Reaction, Cognitive Performance

In brief

The objective of this study is to test the effects of transcutaneous auricular neurostimulation (tAN) in treating or preventing performance degradation after an acute stressor.

Key facts

Study ID

NCT06390267

Run by

Spark Biomedical, Inc.

People needed

43

Starts

2024-11-26

Expected to finish

2025-06-18

Last updated by the study team

2025-08-01

Who can join

Age: 18 and older, up to 41. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adults 18 to 41 years old
• Participant has the cognitive and physical abilities to carry out the study tasks
• Proficient in the English language
• Ability to understand the explanations and instructions given by the study personnel

You may not qualify if…

• Participant presents current evidence of an uncontrolled and/or clinically significant medical condition or psychiatric condition
• Participant has used any psychological stress-management intervention within the last 4 weeks
• Participant is participating in another interventional trial within 90 days prior to or throughout duration of trial
• Participant has a prior diagnosis of post-traumatic stress disorder, acute stress disorder, or generalized anxiety disorder
• Participant is currently using anti-anxiety medications such as Xanax or beta blockers
• Participant has a diagnosis of attention deficit hyperactivity disorder (ADHD) and/or is currently taking medications for the treatment of ADHD.
• History of substance abuse or drug dependence including nicotine and alcohol in the past 3 months
• Participant has abnormal ear anatomy, ear infection present, or earpiercing that could interfere with stimulation
• Participant has a history of epileptic seizures
• Participant has a history of neurologic diseases or traumatic brain injury
• Participant wears or utilized other devices that cannot be removed during the study (e.g., pacemakers, cochlear prostheses, neurostimulators)
• Females who are pregnant or lactating
• Participant has any other significant disease or disorder which, in the opinion of the Investigator, may either put the participants are risk because of participation in the trial, or may influence the result of the trial, or the participant's ability to participate in the trial

Where it is running

• Battelle Memorial Institute — Columbus, Ohio, United States

Full record on ClinicalTrials.gov

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