A Research Study to See How Well Different Doses of CagriSema Help People With Excess Body Weight Lose Weight

Completed · Phase 3 · Has a placebo group

Conditions studied: Obesity

In brief

This study will look at how well CagriSema helps people with excess body weight lose weight. CagriSema is a new medicine developed by Novo Nordisk that combines cagrilintide and semaglutide. CagriSema cannot yet be prescribed by doctors. In the study, participant will either get CagriSema or dummy medicine and which treatment participant get is decided by chance. The study will last for about 1½ years for each participant.

Key facts

Study ID

NCT06388187

Run by

Novo Nordisk A/S

People needed

300

Starts

2024-06-24

Expected to finish

2026-04-22

Last updated by the study team

2026-05-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Male or female
• Age above or equal to 18 years at the time of signing informed consent
• Body Mass index (BMI) greater than or equal to (≥) 30.0 kilogram per meter square (kg/m\^2) or
• BMI ≥27.0 kg/m2 with the presence of at least one obesity related complication including, but not limited to hypertension, dyslipidaemia, obstructive sleep apnoea or cardiovascular disease

You may not qualify if…

• Glycated haemoglobin (HbA1c) ≥6.5% (48 millimoles per mole [mmol/mol]) as measured by the central laboratory at screening
• History of type 1 or type 2 diabetes

Where it is running

• Aurora FDRC Inc. — Costa Mesa, California, United States
• Clinical Trial Res Assoc,Inc — Plantation, Florida, United States
• Midwest Inst For Clin Res — Indianapolis, Indiana, United States
• Accellacare — Wilmington, North Carolina, United States
• Velocity Clinical Res-Dallas — Dallas, Texas, United States
• Washington Cntr Weight Mgmt — Arlington, Virginia, United States
• Capital Clin Res Ctr,LLC — Olympia, Washington, United States
• Ocean West Research Clinic — Surrey, British Columbia, Canada
• Nova Scotia Health Authority — Halifax, Nova Scotia, Canada
• Wharton Medical Clinic Clinical Trials (Hamilton) — Hamilton, Ontario, Canada
• Hospices Civils de Lyon-Hopital Lyon Sud-1 — Pierre-Bénite, France
• Hospices Civils de Lyon-Hopital Lyon Sud — Pierre-Bénite, France
• Centre Hospitalier Universitaire de Nantes-Hopital Nord Laennec — Saint-Herblain, France
• Centre Hospitalier Universitaire de Toulouse-Hopital Rangueil — Toulouse, France
• InnoDiab Forschung GmbH — Essen, Germany
• Wendisch - Dahl Hamburg - DZHW — Hamburg, Germany
• AmBeNet GmbH — Leipzig, Germany
• Institut für Diabetesforschung GmbH Münster - Dr. med. Rose — Münster, Germany
• Forschungszentrum Ruhr KliFoCenter GmbH, Kahrmann — Witten, Germany
• The Health Centre — Bradford-on-Avon, United Kingdom
• Southmead Hospital — Bristol, United Kingdom
• Addenbrooke's Hospital_Cambridge — Cambridge, United Kingdom
• University Hospital Coventry - WISDEM Centre — Coventry, United Kingdom
• Staploe Medical Centre — Soham, United Kingdom
• Joint Clinical Research Facility - Swansea — Swansea, United Kingdom

Full record on ClinicalTrials.gov

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