A Novel Individualized Connectome-guided Approach for Precision Intermittent Theta Burst Stimulation for Depression

Recruiting now · Not applicable

Conditions studied: Depression

In brief

The Investigators propose to carry out a randomized, double-blind trial to compare the clinical efficacy of an individualized connectome-guided accelerated iTBS vs an anatomically-guided (Beam F3) accelerated iTBS. The study team will recruit both inpatients and outpatients who had been referred for TMS for the treatment of depression.

Key facts

Study ID

NCT06385223

Run by

Institute of Mental Health, Singapore

People needed

70

Starts

2024-07-01

Expected to finish

2026-12-31

Last updated by the study team

2024-08-01

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 21 years.
• DSM-5 diagnosis of current Major Depressive Episode.
• Montgomery-Asberg Depression Rating Scale score of 20 or more.
• Inadequate response to an adequate trial (4 weeks) of at least one antidepressant medication.
• Able to give informed consent.

You may not qualify if…

• DSM-5 psychotic disorder
• Drug or alcohol abuse or dependence (preceding 3 months).
• Rapid clinical response required, e.g., high suicide risk.
• Significant neurological disorder, which may pose increased risks with TMS, e.g., epilepsy.
• Metal in the cranium, skull defects, pacemaker, cochlear implant, medication pump or other electronic device.
• Pregnancy.
• Unsuitable for MRI.

Where it is running

• Institute of Mental Health — Singapore, Singapore (enrolling)

Full record on ClinicalTrials.gov

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