Change in Serum Biomarkers After Endovascular Treatment for Acute Anterior Circulation Large Vessel Occlusion
Recruiting now
Conditions studied: Ischemic Stroke
In brief
Acute ischaemic stroke (AIS) results in high rates of neurological morbidity and mortality, especially in patients with large vessel occlusion (LVO). Endovascular therapy (EVT) has been approved as the most effective treatment for patients with LVO , but about half patients undergoing EVT did not achieve good outcome. The mechanisms of poor prognosis are complex. How to accurately identify serological biomarkers related to patients' clinical prognosis is an important research topic nowadays.
Key facts
- Study ID
- NCT06383182
- Run by
- General Hospital of Shenyang Military Region
- People needed
- 200
- Starts
- 2024-07-02
- Expected to finish
- 2026-12-30
- Last updated by the study team
- 2025-08-21
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age: 18-80 years;
- Patients with acute anterior circulation large vessel occlusion within 24 hours of onset who will receive endovascular treatment;
- Pre-stroke mRS: 0-1;
- Baseline NIHSS: ≥6;
- Signed informed consent.
You may not qualify if…
- The presence of contraindications to internal jugular vein cannulation;
- Receiving intravenous thrombolysis;
- Haemorrhagic stroke (cerebral haemorrhage or subarachnoid haemorrhage);
- Coagulation disorders, systemic bleeding tendency, thrombocytopenia (<100×109/L);
- Severe cardiac, hepatic or renal insufficiency (ALT or AST elevated more than 2 times the upper limit of normal value, or serum creatinine elevated more than 1.5 times the upper limit of normal value or in need of dialysis) or other serious medical diseases;
- Severe uncontrolled hypertension (systolic blood pressure greater than 200 mmHg or diastolic blood pressure greater than 110 mmHg);
- Pregnant or lactating women;
- Other conditions who are not suitable for this trial by investigator.
Where it is running
- General Hospital of Northern Theater Command — Shenyang, China (enrolling)
Full record on ClinicalTrials.gov
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