The Role of the Human Microbiome in Patients After Pancreatic Resection.

Enrolling by invitation

Conditions studied: Pancreas Cancer, Pancreas Neoplasm, Pancreas Adenocarcinoma, Periampullary Cancer, Periampullary Carcinoma, Microbial Colonization

In brief

The goal of this observational study is to classify patients that undergo pancreatic resection for presumed pancreatic or periampullary malignancy into high and low risk groups for postoperative complications based on longitudinal saliva, rectal/faecal, tumor, blood and/or bile microbiome profiles. To identify the dynamics of the microbiome, as well as the possibly related short-term and long-term complications, multiple samples at different timepoints are needed from the patients.

Key facts

Study ID

NCT06381882

Run by

St. Antonius Hospital

People needed

200

Starts

2024-06-01

Expected to finish

2026-11-01

Last updated by the study team

2026-04-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patient with a resectable, borderline resectable or locally advanced pancreatic and periampullary presumed (pre)malignancy.
• The intention of the treatment must be curative including surgery and (neo-)adjuvant chemotherapy.
• Willing and able to adhere to the study procedures described in this protocol and to grant the study team access to the electronic patient file and other data that are required to answer the research questions described in this protocol.

You may not qualify if…

• Inability to provide adequate informed consent (e.g. language barrier, illiteracy)

Where it is running

• St. Antonius Hospital — Nieuwegein, Netherlands

Full record on ClinicalTrials.gov

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