Detecting Lymph Node Metastasis in Intrahepatic Cholangiocarcinoma (LyMIC)

Completed

Conditions studied: Cholangiocarcinoma, Cholangiocarcinoma, Intrahepatic, Cholangiocarcinoma Resectable, Cholangiocarcinoma; Liver

In brief

Lymph node metastasis (LNM) is a major prognostic factor in intrahepatic cholangiocarcinoma (ICC), and accurate preoperative prediction of the presence or absence of LNM has significant clinical implications in determining treatment strategy. Despite this, there are currently no reliable biomarkers established to detect LNM in ICC. This study seeks to develop a liquid biopsy assay that can accurately detect LNM before treatment in ICC patients.

Key facts

Study ID

NCT06381648

Run by

City of Hope Medical Center

People needed

230

Starts

2023-04-15

Expected to finish

2025-07-01

Last updated by the study team

2026-03-13

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• A histologically confirmed diagnosis of intrahepatic cholangiocarcinoma.
• Received standard diagnostic and staging procedures as per local guidelines
• Availability of at least one blood-derived sample, drawn before receiving any curative-intent treatment

You may not qualify if…

• Lack of or inability to provide informed consent
• Synchronous Intrahepatic cholangiocarcinoma and non- Intrahepatic cholangiocarcinoma diagnosed at or before surgery
• Secondary liver cancer

Where it is running

• City of Hope Medical Center — Duarte, California, United States
• Department of Gastroenterological Surgery I, Graduate School of Medicine, Hokkaido University — Hokkaido, Sapporo, Japan
• Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University — Fukuoka, Japan
• Department of Surgery, Tokushima University — Tokushima, Japan

Full record on ClinicalTrials.gov

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