Retinal Fundus Flavoprotein Fluorescence in Age Related Macular Degeneration

Completed · Not applicable

Conditions studied: Geographic Atrophy, Age-Related Macular Degeneration

In brief

The goal of this clinical trial is to learn if the areas of stressed cells in the retina correlate to areas of disease identified in standard imaging and whether the images are helpful to identify potential areas of concern before symptoms or disease occurs. The main question it aims to answer is: * to evaluate patterns of increased autofluorescence FPF in the setting of geographic atrophy Participants will undergo FPF imaging using the OcuMet Beacon system.

Key facts

Study ID: NCT06381596
Run by: University of Wisconsin, Madison
People needed: 32
Starts: 2024-04-16
Expected to finish: 2025-05-27
Last updated by the study team: 2026-07-29

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

50 years or older and may be either male or female of any race
Established diagnosis of GA due to AMD
GA characteristics: GA area of between 1.25 mm² and 23 mm², with seventy percent of eyes having GA area ranging from 2.5 mm2 to 17.5 mm2. GA may be unifocal or multifocal. GA may be subfoveal or extrafoveal, with twenty-five percent of eyes having subfoveal GA. The presence of concurrent peripapillary atrophy will not exclude subjects from participation
Willing to participate as evidenced by signing the written informed consent

You may not qualify if…

Unable to tolerate ophthalmic imaging
Presence of neovascular AMD on OCT as confirmed by an ophthalmologist
Presence of significant media opacity preventing adequate retinal imaging
Presence of concurrent retinal disease which may confound assessment

Where it is running

Department of Ophthalmology and Visual Sciences — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

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