Non-steroidal Anti-inflammatory in Cardiac Surgery
Recruiting now · Phase 3 · Has a placebo group
Conditions studied: Acute Postoperative Pain, Non-steroidal Anti-inflammatory Drugs, Cardiac Surgery, Pain Intensity, Multimodal Pain Management
In brief
Non-steroidal anti-inflammatory drugs (NSAID) are part the multimodal strategy in pain management after surgery. However, major concerns are raised in cardiac surgery given the potential side effects of NSAID with more bleeding and acute kidney injury. The investigators hypothesized that NSAID are safe in the early postoperative course after cardiac surgery with respect to contraindication.
Key facts
- Study ID
- NCT06381063
- Run by
- Centre Hospitalier Universitaire, Amiens
- People needed
- 238
- Starts
- 2024-03-27
- Expected to finish
- 2027-07-01
- Last updated by the study team
- 2025-07-23
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- scheduled for cardiac surgery (aortic valve replacement, coronary artery bypass graft, mitral valve repair or replacement, intracardiac tumor, aortic root repair)
- under cardiopulmonary bypass
- Affiliation to the French national healthcare system
- Written consent obtained
You may not qualify if…
- age<18
- weight<50 kg
- chronic use of NSAID
- mini-invasive surgery
- NSAID contraindication
- NSAID allergy
- Nefopam contraindication
- Paracetamol contraindication
- Tramadol contraindication
- Urgent surgery
- Endocarditis
- Immunosuppressive drug
- HIV infection with CD4<200 mm3
- Organ transplantation
- Stage 4 or 5 chronic kidney disease
- Gastro duodenal ulcer
- Pregnancy
- Depression
- Auto immune disease
Where it is running
- CHU Amiens Picardie — Amiens, France (enrolling)
Full record on ClinicalTrials.gov
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