Burn Study- Tranexamic Acid Versus Thrombin in Split Thickness Skin Graft

Recruiting now · Phase 4

Conditions studied: Burns, Skin Graft Complications

In brief

Investigators hypothesize that topical tranexamic acid will have better or comparable efficacy to topical thrombin in reducing hematoma formation at the wound base. The purpose of the study is to demonstrate that topical tranexamic acid will be a non-inferior alternative medication to the current standard of care,THROMBIN-JMI® , and at a lower cost to the health system.

Key facts

Study ID

NCT06379724

Run by

University of Kansas Medical Center

People needed

62

Starts

2024-07-11

Expected to finish

2026-12-01

Last updated by the study team

2025-10-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• English or Spanish speaking
• Flame or scald burn injury
• <=10% total body surface area (TBSA) partial thickness
• <= 5% total body surface area (TBSA) deep partial or full thickness
• Skin graft harvested at 1/12 inch depth, meshed 1:1 or pie crusted if the area is a small functional area

You may not qualify if…

• >10% total body surface area (TBSA) partial thickness burn
• >5% total body surface area (TBSA )surgical area of burn injury (deep partial or full thickness injury)
• Traumatic or chemical burn mechanism
• Patients on immunosuppression
• Uncontrolled diabetes
• Known diagnosis of peripheral vascular disease or diagnosis at time of injury
• Pregnant women
• Patients with acquired defective color vision
• Patients with subarachnoid hemorrhage
• Patients with active intravascular clotting or known hypersensitivity reactions to tranexamic acid
• Inability to give informed consent

Where it is running

• The University of Kansas Health System — Kansas City, Kansas, United States (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.