High Flow Nasal Cannula Rates in Pediatric Asthma

Withdrawn before enrolling · Not applicable

Conditions studied: Pediatric Asthma

In brief

This is a randomized, open-label, 3-armed feasibility trial will examine conventional oxygen therapy (COT) vs high flow nasal cannula at 4L/min flow vs HFNC at 2L/kg/min flow (max 60L/min) in moderate to severe pediatric asthma exacerbations.

Key facts

Study ID

NCT06379607

Run by

University of Rochester

People needed

0

Starts

2025-01-15

Expected to finish

2026-09-30

Last updated by the study team

2026-03-27

Who can join

Age: 2 and older, up to 17. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 2-17 years old with prior clinical diagnosis of asthma
• Admitted to PICU on standard asthma therapy defined as continuous albuterol and systemic corticosteroids
• Admitted to PICU on either COT or HFNC
• Admitted to PICU from either Golisano Children's Hospital ED or as a transport from an outside hospital ED within 6 hours of initial presentation
• PRAM score greater than or equal to 4 after completion of initial ED therapy

You may not qualify if…

• Admitted to the PICU on NIV or invasive mechanical ventilation
• Admitted to the PICU from general floors or > 6 hours from initial presentation
• Presence of a tracheostomy or baseline NIV requirement
• Pregnancy
• Immunocompromised State

Where it is running

• University of Rochester Golisano Children's Hospital — Rochester, New York, United States
• University of Rochester Medical Center — Rochester, New York, United States

Full record on ClinicalTrials.gov

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