BAI-BACE for Advanced Lung Squamous Cell Carcinoma

Recruiting now · Not applicable

Conditions studied: Squamous Cell Carcinoma

In brief

Bronchial arterial infusion plus bronchial arterial chemoembolization (BAI-BACE) has been reported as non-first-line therapy to treat lung cancer in many hospitals in China. BAI, which uses chemotherapeutic drugs directly injected into the tumor and achieved a high concentration in a short time to kill the tumor. Then BACE could seal off the tumor vessels. In this study, we aim to describe the efficacy and safety of BAI-BACE as non-first-line for advanced lung squamous cell carcinoma.

Key facts

Study ID

NCT06377735

Run by

Sun Yat-sen University

People needed

85

Starts

2024-05-01

Expected to finish

2026-12-30

Last updated by the study team

2024-08-09

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Squamous cell carcinoma diagnosed by pathology, and central location by imaging;
• Age 18-80;
• Patients failed to the standard first-line or second-line treatment;
• Tumors limited in the chest;
• Tumors were fed by bronchial artery through CTA reconstruction;
• Patents received PD-1 inhibitor or not were also included;
• Eastern Cooperative Oncology Group performance status (ECOG PS) of 0-2;
• Images within 2 weeks before inclusion;
• Life expectancy more than 3 months;
• Agreed to participated in this clinical trial;
• Hemameba ≥3.0 x109/L, neutrophil ≥1.5x109/L, hemoglobin≥10.0 g/L, platelet≥100x 109/L, ALT; AST; bilirubin ≤1.5-fold normal, GFR≥60ml/min.

You may not qualify if…

• Contraindication of BAI or BACE;
• Under 18 years or over 75 years;
• extra-chest metastases;
• Receiving other antitumor treatment;
• Severe infection or pregnancy;
• Severe Pulmonary fibrosis and pulmonary artery;
• liver, kidney or poor physical conditions;
• Severe pleural effusion or pericardial effusion;
• Life expectancy less than 3 months.

Where it is running

• Chinese PLA General hospital — Beijing, Beijing Municipality, China (enrolling)

Full record on ClinicalTrials.gov

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