Peer Support for Adolescents and Emerging Adults With Sickle Cell Pain

Recruiting now · Not applicable

Conditions studied: Pain, Sickle Cell Disease

In brief

The study, known as the Peer suppoRt for adolescents and Emerging adults with Sickle cell pain: promoting ENgagement in Cognitive behavioral thErapy (PRESENCE), aims to determine the effectiveness of digital CBT in reducing pain, opioid use, and healthcare utilization among AYAs with SCD. It also seeks to understand the role of personalized peer support in enhancing engagement and outcomes of digital CBT interventions. By leveraging existing infrastructure for delivering virtual peer support interventions, tailored digital CBT programs for individuals with SCD, and partnerships with CBOs, the study aims to provide valuable insights into the feasibility and effectiveness of digital CBT as a pain management strategy for this vulnerable population.

Key facts

Study ID

NCT06374238

Run by

University of Pittsburgh

People needed

470

Starts

2025-03-10

Expected to finish

2028-05-01

Last updated by the study team

2026-01-07

Who can join

Age: 16 and older, up to 30. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Aged 16 to 30 years of age at time of enrollment
• Sickle Cell Disease diagnosis of any genotype based on referral or documentation
• Reports chronic pain (≥4 days/week for past 3 months or more) OR A) Being prescribed pain medication to be taken (≥4 days/week for past 3 months or more) OR B) Taking pain medication (≥4 days/week for past 3 months or more) OR C) Receiving non-pharmaceutical pain treatment (≥4 days/week for past 3 months or more)
• Access to an iOS or Android mobile device with internet access

You may not qualify if…

• Unable to speak or read English
• Prior hematopoietic stem cell transplant for sickle cell disease

Where it is running

• University of South Alabama Medical Center — Mobile, Alabama, United States (enrolling)
• UCLA Mattel Children's Hospital Ronald Reagan Hospital — Los Angeles, California, United States (enrolling)
• Connecticut Children's Medical Center — Hartford, Connecticut, United States (enrolling)
• Children's Healthcare of Atlanta — Atlanta, Georgia, United States (enrolling)
• Ann and Robert H. Lurie Children's Hospital of Chicago — Chicago, Illinois, United States (enrolling)
• The Regents of the University of Michigan — Ann Arbor, Michigan, United States (enrolling)
• Rutgers New Jersey Medical School — Newark, New Jersey, United States (enrolling)
• Weil Cornell Medical College — New York, New York, United States (enrolling)
• University of Rochester Medical Center — Rochester, New York, United States (enrolling)
• Wake Forest Baptist Hospital — Durham, North Carolina, United States (enrolling)
• East Carolina University Health Medical Center — Greenville, North Carolina, United States (enrolling)
• UPMC University of Pittsburgh Classical Hematology Adult Clinic — Pittsburgh, Pennsylvania, United States (enrolling)
• UPMC Children's Hospital of Pittsburgh — Pittsburgh, Pennsylvania, United States (enrolling)
• Virginia Commonwealth University — Richmond, Virginia, United States (enrolling)

Full record on ClinicalTrials.gov

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