The Role of Proprotein-convertase-subtilisin/Kexin-type 9 in Kidney Damage in Nephrotic Syndrom
Recruiting now
Conditions studied: Hyperlipidemias, Nephrotic Syndrome
In brief
Nephrotic syndrome (NS) is characterized by gross proteinuria (\>3.5 g/day), hypoalbuminaemia, edema and often hyperlipidemia. Hyperlipidemia is correlated with increased morbidity and mortality. The study aim is to investigate the role of the protein convertase subtilisin/kexin type 9 (PCSK9) in hyperlipidemia of NS, which has been suggested to play an important role. This is done by testing the following hypotheses: 1. PCSK9 is increased in patients with NS and hyperlipidemia compared to kidney-healthy controls 2. The level of PCSK9 in plasma correlates to the degree of proteinuria. 3. PCSK9 i increased in the kidney tissue of patients with NS The study will compare plasma levels of PCSK9 in correlation with degree of protein in the urine between test persons with NS and kidney healthy controls. Furthermore the investigators will study the the degree of PCSK9 in the kidney in biopsies obtained from test persons with nephrotic syndrome and test persons without proteinuria.
Key facts
- Study ID
- NCT06373913
- Run by
- Kolding Sygehus
- People needed
- 75
- Starts
- 2023-06-01
- Expected to finish
- 2028-07-30
- Last updated by the study team
- 2025-09-09
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- 18 years old
- Patients admitted to the Medical Department and/or the Medical Emergency Department, Kolding Sygehus.
You may not qualify if…
- Refusal to give informed consent
- Treatment with PCSK9 inhibitors
- Any acute or chronic condition that would limit the ability of the patient to participate in the study
- Control group: proteinuria
Where it is running
- Kolding Sygehus, Lillebælt Hospital — Kolding, Denmark (enrolling)
Full record on ClinicalTrials.gov
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