Cold Saline Irrigation Before Endobronchial Biopsy

Stopped early · Not applicable

Conditions studied: Lung Diseases

In brief

Patients undergoing an endobronchial ultrasound and biopsy can experience bleeding during the biopsy. These biopsies are read in real time by pathologists who travel to the endoscopy unit during the procedure. Often, when this happens, the blood contaminates the pathology slides making the slide unreadable. This then requires more biopsies to be performed, thus prolonging the procedure, and increasing anesthesia time. One innovative way to reduce bleeding may be to irrigate the bronchial wall with cold saline, where the biopsy is to be taken, immediately before biopsy, thus causing vasoconstriction and possibly resulting in less blood contamination on the biopsy slides. The current study will evaluate this prophylactic irrigation with saline to control bleeding, thus resulting in a quicker diagnostic result of the biopsies.

Key facts

Study ID

NCT06373224

Run by

TriHealth Inc.

People needed

6

Starts

2023-12-01

Expected to finish

2025-12-30

Last updated by the study team

2026-04-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Undergoing an endobronchial ultrasound and biopsy at Bethesda North Hospital

You may not qualify if…

• Under 18 years old
• Does not speak English
• Unable to consent to involvement in the research study
• Is pregnant
• Has a bleeding disorder/diagnosis
• Currently taking anticoagulant medications and not stopped for procedure
• Documented low platelets (<100,000)
• Had a biopsy taken immediately prior to the endobronchial ultrasound

Where it is running

• Bethesda North Hospital — Cincinnati, Ohio, United States

Full record on ClinicalTrials.gov

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