A Study of Tirzepatide (LY3298176) Plus Mibavademab Compared With Tirzepatide Alone in Adult Participants With Obesity

Completed · Phase 2 · Has a placebo group

Conditions studied: Obesity

In brief

The main purpose of this study is to determine if combining tirzepatide with mibavademab will result in more weight loss in adult participants than tirzepatide alone. The study will last about 74 weeks and may include up to 19 visits.

Key facts

Study ID

NCT06373146

Run by

Eli Lilly and Company

People needed

392

Starts

2024-04-24

Expected to finish

2026-04-02

Last updated by the study team

2026-05-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Have a body mass index (BMI) of ≥30 kilogram/square meter (kg/m²) and ≤40 kg/m²
• Willing to learn how to self-inject study intervention (visually impaired persons who are not able to perform the injections must have the assistance of a sighted individual trained to inject the study intervention; persons with physical limitations who are not able to perform the injections must have the assistance of an individual trained to inject the study intervention)
• Male or female contraceptive use by participant should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies.

You may not qualify if…

• Have a history of diabetes mellitus, including Type 1 Diabetes Mellitus (T1DM) or Type 2 Diabetes Mellitus (T2DM), history of ketoacidosis, or hyperosmolar state/coma
• Have a self-reported change (increase or decrease) in body weight >5 kilogram (kg) within 3 months prior to screening
• Have a family or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia (MEN) syndrome type 2
• Have acute or chronic hepatitis
• Have a history of an active or untreated malignancy or are in remission from a clinically significant malignancy for less than 5 years

Where it is running

• Velocity Clinical Research, Gardena — Gardena, California, United States
• Irvine Clinical Research — Irvine, California, United States
• Velocity Clinical Research, Los Angeles — Los Angeles, California, United States
• Velocity Clinical Research, North Hollywood — North Hollywood, California, United States
• Velocity Clinical Research, Santa Ana — Santa Ana, California, United States
• Velocity Clinical Research, Panorama City — Van Nuys, California, United States
• Diablo Clinical Research, Inc. — Walnut Creek, California, United States
• Solaris Clinical Research — Meridian, Idaho, United States
• Tandem Clinical Research — Marrero, Louisiana, United States
• Velocity Clinical Research - New Orleans — New Orleans, Louisiana, United States
• Hassman Research Institute Marlton Site — Marlton, New Jersey, United States
• Lillestol Research — Fargo, North Dakota, United States
• CTI Clinical Research Center — Cincinnati, Ohio, United States
• South Texas Clinical Research — Corpus Christi, Texas, United States
• Velocity Clinical Research, Dallas — Dallas, Texas, United States
• Juno Research — Houston, Texas, United States
• Northwest Clinical Research Center — Bellevue, Washington, United States

Full record on ClinicalTrials.gov

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