Use of Ketosis in Modulating Metabolic Pathways in Bipolar Disorder
Recruiting now · Not applicable
Conditions studied: Bipolar Disorder, Bipolar Disorder Type 1
In brief
The goal of this clinical trial is to test how specific components of diet affect brain function and behavior for individuals with bipolar. The main question it aims to answer is how glucose and ketones each affect the brain's response to risk and reward. Participants will be asked to provide blood (to assess baseline measures of how the body uses energy), and then to receive two MRI scan sessions, on separate days. During each MRI scan session, participants will play three games, from which they can win money, before and after drinking glucose (on one day) or ketones (on the other day). Investigators will compare individuals with and without bipolar to test whether the two groups differ in how their brains use energy, and to test how the brain's use of energy affects behavior.
Key facts
- Study ID
- NCT06373016
- Run by
- Stony Brook University
- People needed
- 100
- Starts
- 2024-01-26
- Expected to finish
- 2027-02-01
- Last updated by the study team
- 2026-04-15
Who can join
Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.
Where it is running
- McLean Hospital — Belmont, Massachusetts, United States (enrolling)
- Martinos Center for Biomedical Research, Building 149, 13th Street — Charlestown, Massachusetts, United States (enrolling)
- Laufer Center for Physical and Quantitative Biology , Stony Brook University — Stony Brook, New York, United States
Full record on ClinicalTrials.gov
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