Neo-Sequence 2：NCT Plus Anti-angiogenesis Therapy and Immunotherapy for LADGC
Recruiting now · Phase 2
Conditions studied: Gastric Cancer, Diffuse Type Carcinoma
In brief
The regimen of Albumin paclitaxel+SOX+BEV neoadjuvant therapy lasted for 6 cycles, during which PD-1 monoclonal antibody therapy was interspersed for 4 cycles for locally advanced diffuse gastric cancer.
Key facts
- Study ID
- NCT06371586
- Run by
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
- People needed
- 67
- Starts
- 2024-03-01
- Expected to finish
- 2027-03-01
- Last updated by the study team
- 2024-04-17
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Local advanced diffuse or mixed type gastric cancer detected by pathology and endoscopy;
- Chest, abdomen, and pelvis enhanced CT, neck and supraclavicular ultrasound, gastroscopy, and endoscopic ultrasound were used to diagnose T3-4NanyM0 gastric cancer or gastroesophageal junction cancer (refer to AJCC staging, 8th edition);
- Has not received any anti-tumor treatment for gastric cancer yet;
- Age range from 18 to 75 years old;
- ECOG score 0-1 points;
- Liver and kidney function and blood routine meet the following conditions:
- Neutrophils>1.5G/L, Hb>90g/L, PLT>100G/L; ALT and AST<2.5ULN; TBIL<1.5 ULN; Cr<1.0ULN;
- Left ventricular ejection fraction>60%;
- Good compliance and ability to accept long-term follow-up;
- Sign informed consent.
You may not qualify if…
- Gastrointestinal obstruction or recurrent bleeding cannot be controlled;
- Those who cannot swallow pills;
- Diagnose immunodeficiency or active autoimmune diseases, have received or are currently receiving immunomodulators, systemic steroid therapy, or immunosuppressive drugs within the past two years;
- Interstitial pneumonia;
- Moderate to severe cirrhosis caused by any reason;
- Uncontrollable hypertension, severe kidney disease, and significant cardiovascular and cerebrovascular diseases;
- Active infections that require systemic treatment;
- Previously suffered from other tumors, excluding cured skin cancer and cervical cancer in situ;
- Internal medicine diseases that do not meet the chemotherapy criteria at the same time;
- Pregnant and lactating patients;
- Individuals with a history of mental illness and poor compliance.
Where it is running
- Cancer hospital，Chinese acadamy of medical sciences — Beijing, China (enrolling)
Full record on ClinicalTrials.gov
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