ABUNDANCE of A NATURAL ODOUR in HUMAN CEREBROSPINAL FLUID AFTER OLFACTORY EXPOSURE - the OLFO-Brain Study

Recruiting now · Early Phase 1 · Has a placebo group

Conditions studied: Overweight and Obesity

In brief

The goal of this clinical trial is to investigate the abundance of a natural odour in human cerebrospinal fluid in obese and lean participants after inhalation thereof. Participants will undergo blood sample collection and inhalation of either a natural odour or placebo through an inhaler in addition to a liquor puncture prescribed in standard of care context.

Key facts

Study ID

NCT06370845

Run by

University Hospital, Basel, Switzerland

People needed

32

Starts

2026-04-14

Expected to finish

2027-10-30

Last updated by the study team

2026-05-04

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may not qualify if…

• Known allergy to the natural odour
• Acute upper respiratory tract infection, acute or chronic sinusitis
• Present or past surgical intervention of the nasal cavity, the paranasal sinus, the pituitary or the frontal brain
• Pregnancy/lactation
• Any kind of severe chronic disease (e.g. severe heart failure, active cancer disease, severe renal impairment with an estimated glomerular filtration rate <30 ml/min/m2)
• Inability to understand the study procedure and to sign the study consent

Where it is running

• University Hospital of Basel — Basel, Switzerland (enrolling)
• University Hospital Basel — Basel, Switzerland

Full record on ClinicalTrials.gov

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