Monetary Incentive Delay Task for Probing Reward-related Neural Processes
Recruiting now · Not applicable
Conditions studied: Adolescent Development
In brief
150 males and 150 females ages 14-17 years-old will be enrolled in an observational, longitudinal study. There are three planned in-person visits: a baseline assessment, an 18-month follow-up, and a 36-month follow-up. The in-person visits will include assessment of substance use and other individual differences (e.g., reward function, psychiatric history), neuromelanin-sensitive MRI, as well as functional brain activation collected while the participant is at rest (resting-state fMRI) and while the participant completes a Monetary Incentive Delay task. Subjects will also be asked to complete past 90-day substance use assessments remotely every 90 days for 36 months.
Key facts
- Study ID
- NCT06369623
- Run by
- Stony Brook University
- People needed
- 300
- Starts
- 2024-04-06
- Expected to finish
- 2028-11-30
- Last updated by the study team
- 2025-05-15
Who can join
Age: 14 and older, up to 17. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Males and females ages 14-17 years-old;
- English-speaking for assent and interview completion;
- Capacity to provide assent.
- For parents, the inclusion criteria will be willing and capacity to provide parental permission/consent.
You may not qualify if…
- current (within 6 months) use of medication that may affect cerebral function
- history of severe medical or neurological illness, including stroke or seizure;
- history of head trauma with loss of consciousness;
- presence of metal in the body;
- pregnancy or breastfeeding;
- recent drug or alcohol use determined by positive urine toxicology or breathalyzer (to validate self-report assessment of substance use history);
- lifetime use of psychotropic or other medication that could likely influence dopamine function, namely stimulant medication or antipsychotic medication, except a subgroup of 25 youth with history of prescribed stimulant medication and a subgroup of 15 youth with history antipsychotic medication will be enrolled for comparison purposes.
Where it is running
- Stony Brook Medicine — Stony Brook, New York, United States (enrolling)
Full record on ClinicalTrials.gov
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