Mechanism Study of Ventilator-Induced Lung Injury in Elderly People.

Recruiting now

Conditions studied: Ventilator-Induced Lung Injury

In brief

1. We collect lung tissues from patients with different ages and confirm that KLK8 expression is positively correlated with age. 2. We collect peripheral blood from patients with different ages and duration of mechanical ventilation to explore the correlation between the degree of endothelial/epithelial damage, age and duration of mechanical ventilation.

Key facts

Study ID

NCT06367946

Run by

Xinhua Hospital, Shanghai Jiao Tong University School of Medicine

People needed

1000

Starts

2023-06-01

Expected to finish

2027-06-30

Last updated by the study team

2024-04-16

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Lung tissues from patients with different ages:
• Patients undergoing elective general anesthesia surgery; Patients undergoing partial lung resection with mechanical ventilation; American Society of Anesthesiology (ASA) grade 2-3;
• Peripheral blood from patients with different ages and duration of mechanical ventilation:
• Patients undergoing elective general anesthesia surgery with mechanical ventilation; ASA grade 2-3;

You may not qualify if…

• Lung tissues from patients with different ages:
• Patients with chronic lung diseases (asthma, chronic obstructive pulmonary disease (COPD), pulmonary heart disease, etc.); Patients with human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis D virus (HDV), or receiving immunotherapy; Patients who have recently suffered from pneumonia; Recent history of mechanical ventilation; Patients with thrombotic diseases; Children and pregnant women.
• Peripheral blood from patients with different ages and duration of mechanical ventilation:
• Patients with chronic lung diseases (asthma, COPD, pulmonary heart disease, etc.); Smoking patients; Patients with hypertension/diabetes/coronary heart disease; Patients with HIV, HBV, HCV, HDV, or receiving immunotherapy; Patients who have recently suffered from pneumonia; Recent history of mechanical ventilation; Patients with thrombotic diseases; Children and pregnant women.

Where it is running

• Shanghai Xinhua hospital — Shanghai, China (enrolling)

Full record on ClinicalTrials.gov

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