Opioid-Free Combined Anesthesia With Spontaneous Breathing for VATS

Recruiting now · Not applicable

Conditions studied: Video-assisted Thoracoscopic Lung Surgery；Anesthesia

In brief

Non-tracheal intubated combined anesthesia with preserved spontaneous breathing significantly enhances the quality and speed of recovery post-VATS for patients undergoing lung nodule surgery. The "opioid-sparing strategy," which substitutes ketamine for opioids during surgery, not only provides effective analgesia but also protects perioperative lung function and reasonably prevents the occurrence of opioid-related adverse reactions; it also reduces medical costs and shortens the average hospital stay. However, the degree of benefit to patients lacks high-level clinical evidence. This study aims to comprehensively assess the effect of opioid-free combined anesthesia with preserved spontaneous breathing for VATS lung nodule surgery on postoperative rapid recovery from multiple aspects including postoperative lung function and pulmonary complications, pain, gastrointestinal function, nausea/vomiting, cognitive function, and depression/anxiety, intending to expand the dataset and application prospects in this field, and increase feasibility experience.

Key facts

Study ID

NCT06367218

Run by

Tongji Hospital

People needed

480

Starts

2024-10-01

Expected to finish

2026-08-01

Last updated by the study team

2025-01-03

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• ASA grades 1-2
• Age > 18 years and < 70 years
• Male or female patients
• VATS pulmonary nodule operation is planned under general anesthesia
• Voluntarily participate in the study and sign the informed consent

You may not qualify if…

• Subject's operation is aborted
• Serious adverse events, complications or special physiological changes during the perioperative period should not be continued
• Expansion of surgical scope: resection of complex lung segment or complex lung lobectomy, thoracoscopic assisted small-incision surgery with enlarged incision, requiring pulmonary blood Tracheoplasty or bronchoplasty, partial pericardiectomy or conversion to thoracotomy
• Those who need a second operation within a month
• The patient or his/her guardian requests to withdraw on his/her own
• Reasons why other researchers think the study needs to be discontinued

Where it is running

• Tongji Hospital — Wuhan, Hubei, China (enrolling)

Full record on ClinicalTrials.gov

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