Diluted Aqueous Povidone-Iodine Compared to Saline to Decrease Surgical Site Infections

Recruiting now · Phase 3

Conditions studied: Surgical Site Infection

In brief

This is a multicenter randomized controlled trial of 1100 patients to evaluate the superiority of combined intraoperative wound irrigation with intraoperative peritoneal lavage with dilute aqueous povidone-iodine compared to normal saline in male and female patients between the ages of 18 and 80 years old undergoing emergency laparotomies with Centers for Disease Control (CDC) class 2 and 3 wounds.

Key facts

Study ID

NCT06363877

Run by

Loma Linda University

People needed

1100

Starts

2024-06-03

Expected to finish

2026-11-01

Last updated by the study team

2025-11-19

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18 to 80 years of age
• undergoing an exploratory laparotomy for Centers for Disease Control class II and III wounds

You may not qualify if…

• Pregnancy
• Preoperative abdominal wall skin/soft tissue infection
• Iodine allergy
• Patients unlikely to survive beyond 30 days
• Patients with mesh placement or placement of a foreign body except for drains

Where it is running

• Loma Linda University Health — Loma Linda, California, United States (enrolling)

Full record on ClinicalTrials.gov

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