Driving Pressure-guided Lung Protective Ventilation
Recruiting now · Not applicable
Conditions studied: Hypoxemia, Ventilator Lung
In brief
The study, named as "The Efficacy of Driving Pressure-guided Lung Protective Ventilation in Surgical Repair of Acute Type A Aortic Dissection: an open-label, randomized control clinical trial", aims to investigate whether driving pressure-guided lung protective ventilation can reduce postoperative oxygenation function in patients who have undergone surgical repair of acute type A aortic dissection. The primary outcomes is the incidence of postoperative hypoxemia (a partial pressure of arterial oxygen to inspiratory oxygen fraction ratio less than 300 mm Hg or a peripheral blood oxygen saturation less than 93% at any concentration of inspiratory oxygen) within 7 days after the surgery.
Key facts
- Study ID
- NCT06361420
- Run by
- Yong Lin, PhD
- People needed
- 43
- Starts
- 2024-01-26
- Expected to finish
- 2025-12-31
- Last updated by the study team
- 2025-08-11
Who can join
Age: 14 and older, up to 70. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Able to sign Informed Consent and Release of Medical Information Forms;
- Age ≥ 14 years and ≤ 70 years old;
- Being confirmed the diagnosis by chest computed tomography angiography and receiving the surgical repair of acute type A aortic dissection.
You may not qualify if…
- Age < 14 years or > 70 years old;
- Sepsis before surgery;
- Chronic pulmonary disease including lung infection or asthma requiring long-term pharmacotherapy;
- History of lung tumor;
- Obstructive sleep apnea hypopnea syndrome requiring long-term noninvasive mechanical ventilation support;
- Heart failure requiring catecholamines or invasive mechanical ventilation support;
- Body mass index > 30 Kg·m-2;
- Being reluctance to participate this study.
Where it is running
- Fujian medical university union hospital — Fuzhou, Fujian, China (enrolling)
Full record on ClinicalTrials.gov
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