Sensory and Cognitive Predictions, and Their Disruptions in Schizophrenia

Recruiting now · Not applicable

Conditions studied: Schizophrenia, Sensory Processing Disorder

In brief

Disturbances in the sense of self and time could play an important role in the development of psychotic symptoms. Previous work has shown that patients have difficulty preparing to process information on the scale of a second, but are abnormally disturbed by slightly asynchronous information on the millisecond scale. In both cases, the anomalies could explain the patients' unusual experience of time. The hypothesis in neurotypical patients is that small delays or asynchronies asynchronies are treated as irrelevant information and ignored and ignored, whereas in patients suffering from schizophrenia they would disrupt the flow of time. This hypothesis is tested with a new visual illusion.

Key facts

Study ID

NCT06361407

Run by

Centre Psychothérapique de Nancy

People needed

68

Starts

2024-06-28

Expected to finish

2027-10-28

Last updated by the study team

2026-03-25

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Male or female;
• Age between 18 and 60 inclusive;
• Subject having dated and signed the consent form prior to the start of any trial-related procedure (guardian or curator where applicable);
• Member of a social security scheme or beneficiary of such a scheme.

You may not qualify if…

• Psychoactive substance use disorders (as defined by the DSM-V) (Diagnostic and Statistical Manual-V);
• Use of benzodiazepines, hallucinogens (in the period preceding before inclusion, for a duration equivalent to 5 half-lives of the product) or cannabis (in the 2 months preceding inclusion);
• Neurological pathology or sequelae;
• Attention deficit hyperactivity disorder (ADHD);
• Borderline personality disorder;
• Disabling sensory disorders (visual acuity <0.8);
• Person deprived of liberty or under court protection;
• Pregnant, parturient or breast-feeding women;
• Subjects in a period of exclusion defined by another clinical study.

Where it is running

• CHU Sainte Marguerite, APHM — Marseille, France (enrolling)
• Centre Hospitalier Drôme Vivarais — Montéléger, France (enrolling)

Full record on ClinicalTrials.gov

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