Radiotherapy vs Catheter Ablation for Ventricular Tachycardia in Structural Heart Disease
Recruiting now · Not applicable
Conditions studied: Ventricular Tachycardia, Cardiomyopathies, Arrhythmias, Cardiac, Ventricular Arrythmia
In brief
The goal of this randomized clinical trial is to test the efficacy of stereotactic body radiation therapy (SBRT) in treating ventricular tachycardia (VT) in patients with advanced structural heart disease. The main questions it aims to answer are: * What is the efficacy of SBRT compared to catheter ablation (CA) in achieving a ≥ 75% reduction in VT burden at 6 months * What is the comparable safety profile of SBRT vs CA Researchers will compare SBRT and CA (standard of care).
Key facts
- Study ID
- NCT06360939
- Run by
- Western Sydney Local Health District
- People needed
- 60
- Starts
- 2025-11-03
- Expected to finish
- 2027-12-20
- Last updated by the study team
- 2026-02-18
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Structural heart disease (including ischaemic cardiomyopathy , non-ischaemic cardiomyopathy or congenital heart disease and defined as any one of
- segmental or global decreased ventricular wall motion as defined by TTE, CT or cMRI
- myocardial hypertrophy
- myocardial scar (evidenced by late gadolinium enhancement on cMRI, wall thinning on cardiac CT, low voltage on electrophysiological study or abnormal intracardiac echocardiography)
- Recurrent monomorphic VT which can include
- at least one episode of VT treated by ICD and/or
- sustained VT (lasting >30s) and/or
- inducible sustained VT on invasive electrophysiological study (EPS) or non-invasive programmed stimulation (NIPS)
- PAINESD score of ≥9 points and/or at least moderate risk of VT recurrence or death as defined by the I-VT score. Both are validated tools used clinically to identify patient at high risk of VT recurrence and/or mortality after CA.
You may not qualify if…
- Age < 18 years
- Life expectancy < 3 months
- Catheter ablation deemed futile or with prohibitive risk by cardiac electrophysiologist.
- Unwilling or unable to provide consent
- Known cardiac channelopathies (e.g. Catecholaminergic polymorphic ventricular tachycardia (CPVT), long- or short QT syndrome, Brugada syndrome)
- Contraindications to radiotherapy as deemed by referring physician and/or radiation oncologist
- Pregnancy or breast feeding
Where it is running
- Westmead Hospital — Westmead, Australia (enrolling)
Full record on ClinicalTrials.gov
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