Metformin and Esomeprazole in Preterm Pre-eclampsia

Stopped early · Phase 4

Conditions studied: Preeclampsia Severe, Pre-Eclampsia, Preeclampsia, Preeclampsia Second Trimester, Preeclampsia Complicating Childbirth, Preeclampsia Puerperium, Preterm

In brief

The purpose of this study is to better understand diagnosis and treatment of preterm preeclampsia. Currently, there are limited laboratory tests that can be used to diagnosis preeclampsia. Additionally, there are few treatments for this condition. This clinical trial will explore treatment options, Metformin and Esomeprazole, as well as serum markers that could improve the diagnosis and treatment of preterm preeclampsia.

Key facts

Study ID: NCT06359015
Run by: Christiana Care Health Services
People needed: 4
Starts: 2021-02-11
Expected to finish: 2025-05-08
Last updated by the study team: 2025-05-31

Who can join

Age: 18 and older, up to 60. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

Women 18 years or older
Women diagnosed with preeclampsia or preeclampsia with severe features or superimposed preeclampsia with chronic hypertension
Candidates for expectant management and had no clinical indication for immediate delivery

You may not qualify if…

Delivery within 48hr is highly likely
Maternal or fetal compromise that necessitated immediate delivery
Diabetes or gestational diabetes currently on metformin therapy
Reflux disease or other conditions currently on esomeprazole
Contraindications to metformin, esomeprazole
Baseline creatinine >124 μmol/L
Hypersensitivity to metformin or esomeprazole
Current use of metformin or esomeprazole
Metabolic acidosis
Use of drugs that might interact with metformin (glyburide, furosemide, or cationic drugs)
Multiple gestations

Where it is running

Christianacare Health System — Newark, Delaware, United States

Full record on ClinicalTrials.gov

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