Clinical Study of Desuzumab in the Treatment of Knee Osteoarthritis
Recruiting now
Conditions studied: Knee Osteoarthritis
In brief
As an activator of inhibiting nuclear factor kB receptor, denosumab affects osteoclast differentiation and development by inhibiting OPG/RANKL-RANK bone regulatory axis pathway. Therefore, denosumab is widely used in the treatment of bone diseases such as osteoporosis. Osteoporosis is closely related to knee osteoarthritis. RANKL-RANK pathway also plays a key role in the pathogenesis of knee osteoarthritis. Therefore, the investigators propose the hypothesis that denosumab can effectively treat knee osteoarthritis.
Key facts
- Study ID
- NCT06357741
- Run by
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- People needed
- 30
- Starts
- 2021-08-01
- Expected to finish
- 2025-12-31
- Last updated by the study team
- 2025-04-09
Who can join
Age: 45 and older, up to 75. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- patients with knee osteoarthritis whose inclusion criteria meet the "diagnostic criteria for arthritis" .
- no drug contraindications .
- aged between 45 and 75 .
- committed to follow the research procedures, And cooperate with the •implementation of the whole process study .
- the patient understands the relevant treatment process .
- the patient has the ability to give informed consent .
- The patient had not recently taken any medication that affected observation.
- the subjects must meet all the inclusion criteria to be eligible to participate in the study .
You may not qualify if…
- mental illness .
- patients with malignant tumors.
- patients with other infectious diseases .
- patients with metabolic bone disease, diabetes and hyperthyroidism.
- patients who cannot actively cooperate in the treatment.
- hypocalcemia.
Where it is running
- Wuhan Union Hospital — Wuhan, Hubei, China (enrolling)
Full record on ClinicalTrials.gov
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