Aprepitant Treatment to Prevent Postoperative Nausea and Vomiting in Children Undergoing Scoliosis Surgery

Recruiting now · Phase 2 · Has a placebo group

Conditions studied: Spinal Fusion, Nausea and Vomiting, Postoperative, Anesthesia

In brief

This research trial will measure how useful Aprepitant is in preventing nausea and vomiting in children having surgery to correct scoliosis (curvature of the spine).

Key facts

Study ID

NCT06357234

Run by

IWK Health Centre

People needed

100

Starts

2025-03-17

Expected to finish

2027-09-01

Last updated by the study team

2026-04-27

Who can join

Age: 8 and older, up to 19. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Posterior Spinal Instrumentation and Fusion (PSIF) for idiopathic scoliosis
• The fusion must include at least 6 vertebral levels.
• Children greater than or equal to 8 years old, and less than 19 years old on the day of surgery
• Weight > 40kg - for ease of pharmacy preparation (PONV dose 1mg per kg to max 40mg)

You may not qualify if…

• Patient/ Parent refusal
• Hypersensitivity to Aprepitant or any ingredient in the formulation or oral solution. (previous allergy or adverse reaction to Aprepitant)
• Developmental delay as reported by parents
• Pregnant - Pregnancy test done as standard of care pre-operative
• Severe systemic disease ASA classification III or greater
• Concurrent use of any medication with severe interaction with Aprepitant as outlined in product monograph.
• Neuromuscular or congenital scoliosis
• Inability to take PO medications

Where it is running

• IWK Health Sciences Center — Halifax, Nova Scotia, Canada (enrolling)

Full record on ClinicalTrials.gov

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