Syncope-Asystole Latency Time in Tilt Table Test: The SALT-TILT Study

Recruiting now

Conditions studied: Syncope, Pacemaker, Asystole, Neurally Mediated Syncope

In brief

Syncope is a common presenting condition. Pacemaker implantation can significantly reduce syncope recurrences in reflex syncope. However, despite careful selection, a substantial proportion of patients treated with pacemakers suffer recurrences of syncope. It is thought that a pronounced vasodepressor component may hinder the efficacy of pacing in patients, preventing adequate cerebral perfusion during the reflex, thus relativizing the anti-bradycardia function of the pacemaker to prevent syncope. It is hypothesised that the time elapsed from the actual loss of consciousness to the asystole recorded on the ECG during Tilt Table Test may be predictive in terms of response to pacemaker therapy, so this parameter becomes the subject of the present study.

Key facts

Study ID

NCT06356207

Run by

Azienda Ospedaliera di Bolzano

People needed

64

Starts

2024-03-20

Expected to finish

2027-03-01

Last updated by the study team

2024-04-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients eligible for invasive treatment according to the ESC Guidelines for pacing 2021
• Written informed consent

You may not qualify if…

• Other condition which explains syncope cause other than reflex syncope
• Structural heart disease (valvular, ischaemic, cardiomyopathies)
• Pregnancy
• Patient denial to be recorded on video during tilt table test

Where it is running

• Azienda Sanitaria di Bolzano — Bolzano, Italy (enrolling)

Full record on ClinicalTrials.gov

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