OverTTuRe: Characteristics, Treatment Patterns and Outcomes of Patients With ATTR Amyloidosis

Recruiting now

Conditions studied: ATTR Amyloidosis

In brief

The overall aim of this observational study is to generate real-world evidence on the pre- and post-diagnosis disease journeys, including baseline characteristics, treatment patterns and selected clinical, economic, and humanistic outcomes (for example Health Related Quality of Life (HRQoL), Neuropathy impairment score, activities of daily living (ADL) assessments) in patients with ATTR amyloidosis, and to better understand how the disease is presented.

Key facts

Study ID

NCT06355934

Run by

AstraZeneca

People needed

52121

Starts

2023-08-21

Expected to finish

2026-09-30

Last updated by the study team

2026-07-17

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients aged >18 years at study index date AND
• A reported diagnosis code for amyloidosis OR
• A claim for ATTR-specific treatment OR
• A positive biopsy for amyloidosis and positive immunostaining result of biopsy for ATTR

You may not qualify if…

• Evidence of primary (AL) and secondary (AA) amyloidosis AND/OR
• At least one claim/procedure code for stem cell transplant or at least two claims/procedure codes for chemotherapy and autoimmune disease drugs which may represent AL (primary) or AA (secondary) amyloidosis treatments

Where it is running

• Research Site — Lisbon, Portugal (enrolling)
• Research Site — Porto, Portugal (enrolling)
• Research Site — Beijing, China
• Research Site — Changsha, China
• Research Site — Chengdu, China
• Research Site — Guangzhou, China
• Research Site — Wuhan, China
• Research Site — Horsens, Denmark
• Research Site — Berlin, Germany
• Research Site — Lecce, Italy
• Research Site — Messina, Italy
• Research Site — Milan, Italy
• Research Site — Tokyo, Japan
• Research Site — A Coruña, Spain
• Research Site — Barcelona, Spain
• Research Site — Bilbao, Spain
• Research Site — El Palmar, Spain
• Research Site — Huelva, Spain
• Research Site — Las Palmas de Gran Canaria, Spain
• Research Site — Madrid, Spain
• Research Site — Majadahonda, Spain
• Research Site — Palma de Mallorca, Spain
• Research Site — Salamanca, Spain
• Research Site — Valencia, Spain
• Research Site — Södertälje, Sweden

Full record on ClinicalTrials.gov

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