Genetic Architecture of Acute Aortic Syndromes and Aortic Aneurysm.

Recruiting now

Conditions studied: Acute Aortic Dissection, Thoracic Aortic Aneurysm

In brief

The aim of this study is to explore the genetic information associated with the development of TAA and aAD in individuals without history or syndromic features (Marfan syndrome, Ehlers-Danlos syndrome, Turner syndrome etc.) for aortic disease. For this purpose, whole genome sequencing will be performed in patients with documented aortic aneurysm or/and aortic dissection.

Key facts

Study ID

NCT06353607

Run by

University Hospital, Basel, Switzerland

People needed

730

Starts

2024-04-08

Expected to finish

2028-12-31

Last updated by the study team

2025-05-16

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• All adult patients > 18 years who underwent surgery for aAD or TAA intervention at the University Hospital Basel, starting in 2015.
• All patients who will undergo surgery for aAD or TAA at the University Hospital Basel, beginning in 2024.

You may not qualify if…

• Patients will be excluded if they are not able or not willing to provide informed consent.
• Patients with diagnosed heritable vascular disorders, such as Marfan syndrome, Turner Syndrome, Loeyes Dietz and Ehlers-Danlos syndrome.

Where it is running

• University Hospital Basel — Basel, Switzerland (enrolling)

Full record on ClinicalTrials.gov

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