PO Methadone Ortho Outpatient

Starting soon · Phase 3 · Has a placebo group

Conditions studied: Arthroscopic Knee Repair, Arthroscopic Hip Repair

In brief

The goal of this clinical trial is to learn if oral methadone given before surgery works to minimize post-operative pain and opioid usage. The main questions it aims to answer are: Does oral methadone improve post-operative pain scores as compared to standard treatment? Does oral methadone lead to reduced use of post-operative and post-discharge opioid usage as compared to the current standard treatment? Researchers will compare oral methadone to a placebo (a look-alike substance that contains no drug) to assess the questions above. Participants will: Receive either oral methadone or a look-alike placebo before surgery Receive standard intraoperative and immediate post-operative pain control at the anesthesiologist's discretion Be asked about their pain levels in the recovery area Keep a diary of pain and opioid usage over the first 2 days after surgery

Key facts

Study ID

NCT06351215

Run by

Keck School of Medicine of USC

People needed

100

Starts

2025-05-01

Expected to finish

2025-12-15

Last updated by the study team

2025-03-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• medically optimized participants who will undergo elective arthroscopic knee or hip repair

You may not qualify if…

• pregnant or breastfeeding, age under 18, history of respiratory compromise, allergy to opioids, recipient of pre-operative nerve block

Where it is running

• USC Healthcare Consultation 3 — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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