Efficacy and Safety of Angiotensin II Injection Versus Placebo in Patients With Refractory Distributed Shock

Recruiting now · Phase 3 · Has a placebo group

Conditions studied: Vasodilatory Shock

In brief

A randomized, double-blind, placebo-controlled study on the treatment of refractory distributed shock with angiotensin II injection, with a random ratio of 1:1. Assuming a success rate of 25% for the main therapeutic endpoint in the control group and 50% for the experimental group, a total of 214 subjects will be enrolled, including 107 in the experimental group and 107 in the control group.

Key facts

Study ID

NCT06351150

Run by

Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

People needed

214

Starts

2024-07-23

Expected to finish

2027-12-01

Last updated by the study team

2025-01-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• age: 18 years to 75 years old, male or female;
• diagnosis of distributive shock;
• on the basis of the treatment of total vasoactive drugs dose > 0.2 μg/kg/min norepinephrine (or equivalent dose of another vasoactive drug: such as epinephrine > 0.2 μg/kg/min, dopamine > 30 μg/kg/min, phenylephrine > 2 μg/kg/min, vasopressin > 0.08 U/min) and continuous treatment for at least 6 hours and no more than 48 hours, the patient's mean arterial pressure can still only be maintained between 55 and 70 mmHg, or do not reach the target MAP assessed by clinicians, it can be diagnosed as refractory distributive shock.
• have central venous access and arterial catheters, and are expected to be present for at least the first 48 hours of the study.
• indwelling catheter, and expected to be present for at least the first 48 hours of the study.
• patient has received at least 30 mL/kg of crystalloid or colloid volume in the previous 24 hours or has undergone adequate volume resuscitation in the opinion of the investigator.
• patients must have one of the following criteria with clinical features of high-output shock
• Central venous oxygen saturation (ScVO2) > 70% (via saturation catheter or central venous blood gas) and central venous pressure (CVP) > 8 mmHg.
• cardiac index (CI) > 2.3 L/min/m2.
• the patient or legal representative is willing and able to provide written informed consent and comply with all protocol requirements.

You may not qualify if…

• Patients with burns > 20% of total body surface area;
• Patients with cardiovascular (CV) SOFA score ≤ 3;
• Patients with acute coronary syndrome requiring interventional therapy;
• Patients treated with Extracorporeal Membrane Oxygenation (ECMO);
• Patients with end-stage liver failure (Model for end-stage liver disease score (MELD) > 30).
• Patients with a diagnosis of asthma or bronchospasm.
• Patients with a diagnosis of acute mesenteric ischemia, or patients with suspected acute mesenteric ischemia.
• Patients with a history, presence, or high suspicion of aortic dissection or abdominal aortic aneurysm, or patients diagnosed with aortic dissection or abdominal aortic aneurysm.
• Patients who have been diagnosed with malignant tumor within the past 2 years, except for early malignant tumors (carcinoma in situ or stage I tumor) that have been radically treated or expected to recover after treatment, such as adequately treated thyroid cancer, cervical carcinoma in situ, basal cell or squamous cell carcinoma.
• Patients with Raynaud's phenomenon, systemic sclerosis or vasospastic disease.
• Patients with life expectancy ≤ 24 hours as assessed by the study physician.
• Patients with active bleeding who are expected to require transfusion of > 4 units of packed red blood cells within 48 hours of study start.
• Patients with active bleeding and hemoglobin < 7 g/dL or any other condition that contraindicates serial blood sampling.
• Patients with absolute neutrophil count (ANC) < 1000 cells/mm3.
• Patients with known hypersensitivity to angiotensin II injection and its excipients.
• Patients who are currently participating in another interventional clinical trial.
• Blood/urine pregnancy test should be performed for patients with known pregnancy at screening and those with clinical suspicion of pregnancy.
• Patients who are considered unstable by the investigator or have any condition that would affect the safety of the study or the interpretation of the study results, or that would prevent the patient from completing the study, including but not limited to cardiovascular, gastrointestinal, hepatic, renal, neurological, musculoskeletal, infectious, endocrine, metabolic, hematological, psychiatric, or major physical disorders. For example: patients with arrhythmia, uncontrolled hyperglycemia, cerebrovascular disease, uncontrolled hypertension, autoimmune disease requiring daily use of ≥ 500 mg hydrocortisone or equivalent glucocorticoids, etc.

Where it is running

• Shanghai General Hospital — Shanghai, Shanghai Municipality, China (enrolling)
• The Frist Affiliated Hospital of Wannan Medical College — Wuhu, Anhui, China
• Beijing Tiantan Hospital,Capital Medical University — Beijing, Beijing Municipality, China
• Peking Union Medical College Hospital — Beijing, Beijing Municipality, China
• The Frist Affiliated Hospital of Chongqing Medical University — Chongqing, Chongqing Municipality, China
• The people's Hospital of the University of traditional Chinese medicine in Fujian — Fuzhou, Fujian, China
• Gansu Provincial Hospital — Lanzhou, Gansu, China
• The First Affiliated Hospital of Sun Yat sen University — Guangzhou, Guangdong, China
• Zhujiang Hospital of Southern Medical University — Guangzhou, Guangdong, China
• The First Affiliated Hospital of Jinan University — Guangzhou, Guangdong, China
• Qingyuan Hospital Affiliated to Guangzhou Medical University — Qingyuan, Guangdong, China
• The First Affiliated Hospital of Shantou University Medical College — Shantou, Guangdong, China
• Peking University Shenzhen Hospital — Shenzhen, Guangdong, China
• The People's Hospital of Guangxi Zhuang Autonomous Region — Guilin, Guangxi, China
• Liuzhou General Hospital — Liuzhou, Guangxi, China
• The Affiliated Hospital of Guizhou Medical University — Guiyang, Guizhou, China
• The Affiliated Hospital of Hebei University — Baoding, Hebei, China
• The First Affiliated Hospital of Harbin Medical University — Harbin, Heilongjiang, China
• The First Affiliated Hospital of Bengbu Medical College — Bengbu, Henan, China
• The First Affiliated Hospital of Henan University of Science and Technology — Luoyang, Henan, China
• The First Affiliated Hospital of Zhengzhou University — Zhengzhou, Henan, China
• Union Hospital, Tongji Medical College of huazhong university of science and technology — Wuhan, Hubei, China
• Wuhan Third Hospital — Wuhan, Hubei, China
• Xiangya Hospital Central South University — Changsha, Hunan, China
• Hunan Provincial People's Hospital — Changsha, Hunan, China

Full record on ClinicalTrials.gov

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