Development of a New Rapid Diagnostic Test to Support Onchocerciasis Elimination

Recruiting now · Not applicable

Conditions studied: Onchocerciasis, Loiasis, Mansonelliasis, Healthy Volunteers

In brief

Onchocerciasis, also known as river blindness, is one of the disease targeted for elimination by the World Health Organization (WHO) in the group of Neglected Tropical Diseases. Existing diagnostic tools for onchocerciasis have limitations that make mapping, epidemiological assessments and verification of elimination of onchocerciasis difficult. It is in this context that WHO, in its 2021-2030 roadmap for onchocerciasis, has identified the development of new diagnostic tests, or the improvement of existing diagnostic tests, as a critical condition for achieving the goal of eliminating onchocerciasis transmission. To this end, a series of cross-sectional studies will be carried out in Cameroun over a one year period to collect and characterize biological samples for the development and evaluation of a new rapid diagnostic test for onchocerciasis. The study will target individuals aged 18 and over, mono-infected with one of the filarial species Onchocerca volvulus, Loa loa or Mansonella perstans; and non-infected. At the end of this study, data on the endemicity of onchocerciasis, loiasis and mansonellosis in the selected communities will be updated. More importantly, a new rapid diagnostic test will be developed, which can then be used to monitor the activities of onchocerciasis control programs.

Key facts

Study ID

NCT06350851

Run by

Bioaster

People needed

400

Starts

2024-04-15

Expected to finish

2025-12-01

Last updated by the study team

2025-03-07

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Subjects informed of the objectives of the study and who signed a consent form
• Subjects without filariasis (for control subjects), or
• Subjects mono-infected with Onchocerca volvulus, or
• Subjects mono-infected with Loa loa, or
• Subjects mono-infected with Mansonella perstans or alternatively co-infected with Mansonella perstans and Loa loa

You may not qualify if…

• Pregnant or breast-feeding women
• Subjects having taken antihelminthic treatment less than 6 months before the inclusion date

Where it is running

• Higher Institute for Scientific and Medical Research — Yaoundé, Cameroon (enrolling)

Full record on ClinicalTrials.gov

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