Postprandial Inflammation and Nuts (PIN) in Older Adults
Completed · Not applicable
Conditions studied: Healthy Aging, Overweight and Obesity
In brief
The aging population is rapidly increasing, and it is important to identify dietary factors that can prevent disease and promote health in this group. Legumes, such as peanuts, are a plant-based food high in protein and unsaturated fat making this a healthy choice, but are not consumed frequently enough in older adults. Studies have shown that regular nut consumption is associated with lower adiposity and reduced weight gain and inflammation. Given these findings, this study will examine the postprandial effects of meals with 2 levels of saturated fatty acids (SFA) on metabolic endotoxemia, inflammation and satiety, using a randomized cross-over design. The low SFA meal includes peanuts that are high in monounsaturated fatty acids (MUFA) and this will be compared to a high SFA meal. The results of this study have the potential to provide valuable insights into the role of peanuts in promoting health and preventing disease in at-risk older adults.
Key facts
- Study ID
- NCT06348771
- Run by
- Rutgers, The State University of New Jersey
- People needed
- 17
- Starts
- 2024-03-25
- Expected to finish
- 2025-10-07
- Last updated by the study team
- 2026-05-13
Who can join
Age: 55 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Older adults across all racial/ethnic groups
- Older men, and postmenopausal women > 2 years since last menses.
You may not qualify if…
- Anemia
- Diagnosed with, active, or history of liver cirrhosis, chronic or persisting hepatitis
- Diagnosed with, active, or history of cancer
- History of gastrointestinal disease or surgical procedure for weight loss.
- Diagnosed with immune diseases, type 1 or 2 diabetes, pancreatitis, metabolic bone disease or infectious diseases
- Any surgery in the past 6 months
- Currently using or have used antibiotics continuously > 3 days in the past 3 months
- Regular use of medications for that affect the gastrointestinal tract, cholecystitis, urinary tract infection, significant renal disease, severe organic diseases including coronary heart disease, myocardial infarction, infectious diseases including pulmonary tuberculosis and AIDS
- Known allergy or intolerance to any ingredients in the meal intervention
- Recent colonoscopy (within the previous two months)
- Uncontrolled hypertension or uncontrolled severe hyperlipidemia.
- Participation in another clinical research trial that may interfere with the results of this study.
Where it is running
- Foran Hall — New Brunswick, New Jersey, United States
- Rutgers University - NJ Inst Food Nutrition & Health — New Brunswick, New Jersey, United States
Full record on ClinicalTrials.gov
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