NeuroControl of Nicotine Dependence
Recruiting now · Not applicable
Conditions studied: Nicotine Dependence
In brief
The purpose of the study is to examine the effects of continuous theta burst stimulation (cTBS) on different forms of cognitive control in adults who smoke cigarettes, and to determine if the location where cTBS is delivered may help smokers reduce or quit smoking. Participation in the study will take 3-weeks over 4 visits, with a total time commitment of approximately 12 hours.
Key facts
- Study ID
- NCT06347055
- Run by
- University of Missouri-Columbia
- People needed
- 30
- Starts
- 2024-10-01
- Expected to finish
- 2030-04-30
- Last updated by the study team
- 2024-10-01
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Nicotine Dependence as measured by: Smoke ≥ 8 cigarettes/day for ≥ 2 yrs, expired carbon monoxide (CO) concentration of ≥ 10 ppm, positive urine cotinine test and FTND score ≥ 3 Or ≥ 15 uses of electronic cigarette/day for ≥ 1 year, positive urine cotinine test, and PS-ECDI score ≥ 3
- English Fluency
- Functional Vision (with corrective lenses as needed)
You may not qualify if…
- Use of psychotropic and antiepileptic medications in the last month
- Presence of an untreated illness or serious medical condition
- History of major neurological illness
- Contraindication to TMS (history of neurological disorder or seizure, increased intracranial pressure, brain surgery, or head trauma with loss of consciousness for >15 min., implanted electronic device, metal in the head) or MRI.
- Any use of substances that lower seizure threshold.
- Current or past psychosis
- Electroconvulsive therapy in the past 6 months
- Unstable cardiac disease or hypertension, severe renal or liver insufficiency, or sleep apnea
- BAC greater than 0.0.
- Positive urine pregnancy test
- Any other concern that in the investigator's opinion would impact participant safety, study instruction compliance, or confound the interpretation of the study results.
Where it is running
- Health Neuroscience Center — Columbia, Missouri, United States (enrolling)
Full record on ClinicalTrials.gov
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