Ureteroscopy With High-powered Holmium:Yag Laser Lithotripsy With and Moses On or Moses Off

Running, not enrolling · Not applicable

Conditions studied: Kidney Stone, Ureteral Stone

In brief

The purpose of this study is to compare Moses 2.0 pulse modulation technology and the standard high powered Holmium Laser lithotripsy and how it will affect time in the operating room, time using the laser, laser energy, and stone free rates. Currently Moses 2.0 laser technology is FDA approved and currently used in practice since 2021. No study to this date has compared Moses 2.0 without pulse modulation laser technology to Moses 2.0 with pulse modulation laser technology. The study will be including kidney and ureteral stones (a kidney stone located in the tube between the kidney and the bladder) that are 6mm and greater, but less than 20 mm in size undergoing ureteroscopic treatment. High powered lasers are used for "dusting". Dusting is when a laser is used to break a stone down into tiny fragments that are able to pass through the urine.

Key facts

Study ID

NCT06346483

Run by

Northwestern University

People needed

150

Starts

2023-06-09

Expected to finish

2026-09-30

Last updated by the study team

2026-06-04

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Undergoing ureteroscopy and laser lithotripsy
• Stone size ≥8 but < 20 mm in the proximal ureter or kidney. Multiple stones ≤4 are allowed. Bilateral surgeries are allowed
• Willing to sign informed consent

You may not qualify if…

• Staged surgery
• Nephrocalcinosis
• Participant is less than 18 years of age
• Inability to provide informed consent
• Members of vulnerable patient populations

Where it is running

• Northwestern Medicine — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

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