Prediction of Propofol Effect-Site Concentration Associated With Deep Anesthesia

Recruiting now

Conditions studied: Anesthesia

In brief

The goal of this observational study is to explore the variability of the concentration at the effect site (Ce) of propofol to reach deep anesthesia (DA) during induction of general anesthesia in adults. The investigators hypothesized that there is a great variability in this Ce that could be precisely explained by * Electroencephalographic (EEG) features available prior to induction of anesthesia * Cognitive performance * Patients characteristics Participants will undergo preoperative cognitive testing and awake EEG. Then, induction of general anesthesia will be performed using continuous infusion of propofol. The Ce at which Deep anesthesia is observed will be recorded.

Key facts

Study ID

NCT06346158

Run by

Ciusss de L'Est de l'Île de Montréal

People needed

110

Starts

2025-04-07

Expected to finish

2027-01-01

Last updated by the study team

2026-01-16

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Scheduled for any kind of surgery under general anesthesia.
• Adults

You may not qualify if…

• Inability to communicate in French or English,
• Known allergy or intolerance or other medical condition that precludes the use of prescribed general anesthesia protocol for this study,
• Patients requiring rapid sequence induction,
• Anticipated or known difficult intubation patient,
• Anticipated or known difficult ventilation patient,
• Body mass index ≥ 35 kg.m-2.

Where it is running

• Hopital Maisonneuve-Rosemont — Montreal, Quebec, Canada (enrolling)

Full record on ClinicalTrials.gov

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